ICA 121431

Name: ICA 121431
Brand: Tocris Bioscience
SKU: 5066

Tocris Bioscience, part of Bio-Techne | Catalog # 5066

Citations (21)

COA / SDS

Potent and selective NaV1.3 and NaV1.1 channel blocker

Key Product Details

Description:	Potent and selective Na_V1.3 and Na_V1.1 channel blocker
Chemical Name:	α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	449.55

View Full Technical Details for ICA 121431

Technical Data
Citations

Biological Activity for ICA 121431

ICA 121431 is a potent and selective inhibitor of human Na_V1.3 and Na_V1.1 channels (IC₅₀ values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC₅₀ values are >10 μM for human Na_V1.5 and Na_V1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

Compound Libraries for ICA 121431

ICA 121431 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ICA 121431

M. Wt	449.55
Formula	C₂₃H₁₉N₃O₃S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	313254-51-2
PubChem ID	998021
InChi Key	URSQNPPONHUJDL-UHFFFAOYSA-N
Smiles	O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICA 121431

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.95	100

Preparing Stock Solutions for ICA 121431

The following data is based on the product molecular weight 449.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.12 mL	22.24 mL
5 mM	0.44 mL	2.22 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for ICA 121431

References are publications that support the biological activity of the product.

McCormack Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 2013 PMID: 23818614