ICA 121431
Tocris Bioscience, part of Bio-Techne | Catalog # 5066
Potent and selective NaV1.3 and NaV1.1 channel blocker
Key Product Details
Description
Potent and selective NaV1.3 and NaV1.1 channel blocker
Product Description
ICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.Product Specifications
Molecular Weight
449.55
Formula
C23H19N3O3S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
CAS Number
313254-51-2
PubChem ID
998021
InChI Key
URSQNPPONHUJDL-UHFFFAOYSA-N
SMILES
O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.95 | 100 |
Preparing Stock Solutions
for ICA 121431
The following data is based on the product molecular weight 449.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McCormack Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 2013 PMID: 23818614
Product Specific Notices for ICA 121431
For research use only
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