Ibotenic acid

Name: Ibotenic acid
Brand: Tocris Bioscience
SKU: 0285

Catalog # 0285

Citations (4)

COA / SDS

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Key Product Details

Description:	NMDA agonist; also non selective mGlu agonist
Chemical Name:	α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	158.11

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Biological Activity

Ibotenic acid is a NMDA and metabotropic glutamate receptor agonist.

Technical Data

M. Wt	158.11
Formula	C₅H₆N₂O₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	2552-55-8
PubChem ID	1233
InChi Key	IRJCBFDCFXCWGO-UHFFFAOYSA-N
Smiles	NC(C(O)=O)C1=CC(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.58	10
	1.1eq. NaOH	15.81	100

Preparing Stock Solutions

The following data is based on the product molecular weight 158.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.32 mL	31.62 mL	63.25 mL
5 mM	1.26 mL	6.32 mL	12.65 mL
10 mM	0.63 mL	3.16 mL	6.32 mL
50 mM	0.13 mL	0.63 mL	1.26 mL

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References

References are publications that support the biological activity of the product.

Pin and Duvoisin The metabotropic glutamate receptors: structure and functions. Neuropharmacology 1995 PMID: 7623957
Nakanishi Molecular diversity of glutamate receptors and implications for brain functions. Science 1992 PMID: 1329206
Watkins and Evans Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981 PMID: 6112965
Johnston Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 1968 PMID: 5752907

Citations for Ibotenic acid (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Ibotenic acid include:

Joseph et al. (2018) Role of Prefrontal Cortex Anti- and Pro-inflammatory Cytokines in the Development of Abnormal Behaviors Induced by Disconnection of the Ventral Hippocampus in Neonate Rats. Front Behav Neurosci. 12:244
PMID: 30459571
Renouard et al. (2015) The supramammillary nucleus and the claustrum activate the cortex during REM sleep. Neurobiol Learn Mem. 1:e1400177
PMID: 26601158
Karlsson et al. (2013) Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia. Psychopharmacology (Berl). 226:45
PMID: 23010798
Pitts and Takahashi (2011) The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neuroreport. 95:86
PMID: 21093597

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