IB-MECA

Catalog # 1066

Citations (12)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	A₃ selective agonist
Alternative Names:	CF 101, Piclidenoson
Chemical Name:	1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide
Purity:	≥97% (HPLC)
Molecular Weight:	510.29

View Full Technical Details for IB-MECA

Complete Your Research

Biological Activity

IB-MECA is a potent and selective A₃ adenosine receptor agonist (K_i values are 1.1, 54 and 56 nM for A₃, A₁ and A_2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Technical Data

M. Wt	510.29
Formula	C₁₈H₁₉IN₆O₄
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	152918-18-8
PubChem ID	123683
InChi Key	HUJXGQILHAUCCV-MOROJQBDSA-N
Smiles	IC1=CC=CC(CNC2=NC=NC3=C2N=CN3[C@@H]4O[C@H]([C@@](NC)=O)[C@@H](O)[C@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		25

Preparing Stock Solutions

The following data is based on the product molecular weight 510.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.84 mL	39.19 mL	78.39 mL
1.25 mM	1.57 mL	7.84 mL	15.68 mL
2.5 mM	0.78 mL	3.92 mL	7.84 mL
12.5 mM	0.16 mL	0.78 mL	1.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Park N⁶-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3β. J.Pharmacol.Exp.Ther. 2006 PMID: 16611852
Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
Gallo-Rodriguez Structure-activity relationships of N⁶-benzyladenosine-5'-uronamides as A₃-selective adenosine agonists. J.Med.Chem. 1994 PMID: 8126704

Citations for IB-MECA (12)

Showing 1 - 10 of 12 citations Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for IB-MECA include:

Ledderose et al. (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. 2016;
PMID: 27577957
Ford et al. (2015) Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. J.Neurosci.. 35:6057
PMID: 25878279
Eusemann et al. (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One. 10:e0134934
PMID: 26263491
Janes et al. (2014) A3 adenosine receptor agonist prevents the development of PacT.-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain. 155:2560
PMID: 25242567
He et al. (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 27:3446
PMID: 23682121
Kozma et al. (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 85:1171
PMID: 23376019
Stoddart et al. (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 19:1105
PMID: 22999879
Park et al. (2012) Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 82:878
PMID: 22695326
Keene et al. (2010) Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 80:188
PMID: 20346920
Kornerup et al. (2005) Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 144:1011
PMID: 15685200
Feoktistov et al. (2003) Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. J Neurosci. 92:485
PMID: 12600879
Nieri et al. (2001) Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. Br J Pharmacol. 134:745
PMID: 11606314

There are no citations that match your criteria.