HTMT dimaleate
Tocris Bioscience, part of Bio-Techne | Catalog # 0646
H1/ H2 agonist
Key Product Details
Description
H1/ H2 agonist
Alternative Names
Histamine trifluoromethyl toluidide
Product Description
HTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.Product Specifications
Molecular Weight
614.57
Formula
C19H25F3N4O.2C4H4O4
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
CAS Number
195867-54-0
PubChem ID
45073433
InChI Key
ODAOZWTYNWZSBY-SPIKMXEPSA-N
SMILES
[H]OC(=O)\C=C/C(=O)O[H].[H]OC(=O)\C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 61.46 | 100 |
Preparing Stock Solutions
for HTMT dimaleate
The following data is based on the product molecular weight 614.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.14 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Khan Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 1987 PMID: 2959777
- Shahid Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J.
- Khan The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 1986 PMID: 3011908
Product Specific Notices for HTMT dimaleate
For research use only
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