HTMT dimaleate

Name: HTMT dimaleate
Brand: tocris
SKU: 0646

Catalog # 0646

Citations (2)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	H₁/ H₂ agonist
Alternative Names:	Histamine trifluoromethyl toluidide
Chemical Name:	6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
Purity:	≥99% (HPLC)

View Full Technical Details for HTMT dimaleate

Complete Your Experiment

Biological Activity

H₁ and H₂ receptor agonist. 4x10⁴ times more active than histamine in H₂-mediated effects in natural suppressor cells. Increases intracellular Ca²⁺ and IP₃ in lymphocytes through a binding site other than H₁, H₂ or H₃.

Technical Data

M. Wt	614.57
Formula	C₁₉H₂₅F₃N₄O.2C₄H₄O₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	195867-54-0
PubChem ID	45073433
InChi Key	ODAOZWTYNWZSBY-SPIKMXEPSA-N
Smiles	[H]OC(=O)\C=C/C(=O)O[H].[H]OC(=O)\C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	61.46	100

Preparing Stock Solutions

The following data is based on the product molecular weight 614.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.14 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Khan The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 1986 PMID: 3011908
Khan Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 1987 PMID: 2959777
Shahid Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J.

Showing 1-2 of 2 citations

Citations (2)

Citations are publications that use Bio-techne products. Selected citations for HTMT dimaleate include:

Tripathi et al. (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J. 18:411
PMID: 23961154
Mishra et al. (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol. 30:582
PMID: 21139565

HTMT dimaleate

Order Information

Shipping Information

Key Product Details

Complete Your Experiment

Complete Your Research

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected