HTMT dimaleate

Name: HTMT dimaleate
Brand: Tocris Bioscience
SKU: 0646

Catalog # 0646

Citations (2)

COA / SDS

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Key Product Details

Description:	H₁/ H₂ agonist
Alternative Names:	Histamine trifluoromethyl toluidide
Chemical Name:	6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
Purity:	≥99% (HPLC)
Molecular Weight:	614.57

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Biological Activity

HTMT dimaleate is a H₁ and H₂ receptor agonist. 4x10⁴ times more active than histamine in H₂-mediated effects in natural suppressor cells. Increases intracellular Ca²⁺ and IP₃ in lymphocytes through a binding site other than H₁, H₂ or H₃.

Technical Data

M. Wt	614.57
Formula	C₁₉H₂₅F₃N₄O.2C₄H₄O₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	195867-54-0
PubChem ID	45073433
InChi Key	ODAOZWTYNWZSBY-SPIKMXEPSA-N
Smiles	[H]OC(=O)\C=C/C(=O)O[H].[H]OC(=O)\C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	61.46	100

Preparing Stock Solutions

The following data is based on the product molecular weight 614.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.14 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References

References are publications that support the biological activity of the product.

Shahid Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J.
Khan Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 1987 PMID: 2959777
Khan The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 1986 PMID: 3011908

Citations for HTMT dimaleate (2)

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Citations are publications that use Bio-Techne products. Selected citations for HTMT dimaleate include:

Tripathi et al. (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J. 18:411
PMID: 23961154
Mishra et al. (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol. 30:582
PMID: 21139565

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