HS 024

Tocris Bioscience, part of Bio-Techne | Catalog # 1832

COA / SDS

Highly potent MC4 receptor antagonist

Key Product Details

Description:	Highly potent MC₄ receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1266.5

View Full Technical Details for HS 024

Technical Data
Citations

Biological Activity for HS 024

HS 024 is a highly potent melanocortin MC₄ receptor antagonist (K_i values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC₄, MC₁, MC₃ and MC₅ receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Technical Data for HS 024

M. Wt	1266.5
Formula	C₅₈H₇₉N₁₉O₁₀S₂
Single Letter Sequence	CXRHXRWGC (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge: 1-9)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	212370-59-7
PubChem ID	25081552
InChi Key	PUOCNCOPVAOMDE-LQXMKOPKSA-N
Smiles	CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HS 024

Solubility

Soluble to 0.5mg/ml in water

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References for HS 024

References are publications that support the biological activity of the product.

Jonsson Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 2002 PMID: 12065241
Kask Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 1998 PMID: 9832440
Jonsson Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 2001 PMID: 11726778