Honokiol

Name: Honokiol
Brand: Tocris Bioscience
SKU: 4590

Tocris Bioscience a Bio-Techne Brand

Catalog # 4590

Citations (1)

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Key Product Details

Description:	Blocks NF-κB activation; also anti-inflammatory and antioxidant
Chemical Name:	5,3'-Diallyl-2,4'-dihydroxybiphenyl
Purity:	≥98% (HPLC)
Molecular Weight:	266.33

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Biological Activity for Honokiol

Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

Technical Data for Honokiol

M. Wt	266.33
Formula	C₁₈H₁₈O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	35354-74-6
PubChem ID	72303
InChi Key	FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles	OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Honokiol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.63	100
	ethanol	26.63	100

Preparing Stock Solutions for Honokiol

The following data is based on the product molecular weight 266.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.77 mL	37.55 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for Honokiol

References are publications that support the biological activity of the product.

Pillai Nat.Commun. 2015 PMID: 25871545
Kim and Cho Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 2008 PMID: 18158873
Dikalov Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 2008 PMID: 18640101
Ahn Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 2006 PMID: 16966432
Bai Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 2003 PMID: 12816951

Citations for Honokiol (1)

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Citations are publications that use Bio-Techne products. Selected citations for Honokiol include:

Xu et al. (2017) Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. Dis Model Mech. 10:1117
PMID: 28714852

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