HLM 006474

Name: HLM 006474
Brand: Tocris Bioscience
SKU: 5283

Tocris Bioscience, part of Bio-Techne | Catalog # 5283

Citations (2)

COA / SDS

E2F transcription factor inhibitor

Discontinued Product

5283 has been discontinued. View all Additional Transcription Factor Compounds products.

Key Product Details

Description:	E2F transcription factor inhibitor
Chemical Name:	7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol
Purity:	≥98% (HPLC)
Molecular Weight:	399.48

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Technical Data
Citations

Biological Activity for HLM 006474

HLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Technical Data for HLM 006474

M. Wt	399.48
Formula	C₂₅H₂₅N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	353519-63-8
PubChem ID	2895500
InChi Key	CYNZBLNMIJNBSF-UHFFFAOYSA-N
Smiles	CC1=C(OCC)C=CC(C(C3=C(O)C(N=C(C)C=C4)=C4C=C3)NC2=NC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for HLM 006474

References are publications that support the biological activity of the product.

Conklin The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 2012 PMID: 23212373
Ma A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 2008 PMID: 18676853

HLM 006474

Tocris Bioscience, part of Bio-Techne | Catalog # 5283

Key Product Details

Biological Activity for HLM 006474

Technical Data for HLM 006474

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for HLM 006474

Product Documents for HLM 006474

COA

Certificate of Analysis

SDS

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