Histamine dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3545
Endogenous histamine receptor agonist
Key Product Details
Description
Endogenous histamine receptor agonist
Product Description
Histamine dihydrochloride is an endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.Product Specifications
Molecular Weight
184.07
Formula
C5H9N3.2HCl
Storage
Desiccate at RT
Chemical Name
2-(4-Imidazolyl)ethylamine dihydrochloride
CAS Number
56-92-8
PubChem ID
5818
InChI Key
PPZMYIBUHIPZOS-UHFFFAOYSA-N
SMILES
NCCC1=CNC=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.41 | 100 | |
| DMSO | 18.41 | 100 |
Preparing Stock Solutions
for Histamine dihydrochloride
The following data is based on the product molecular weight 184.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.16 mL | 54.33 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.87 mL |
| 10 mM | 0.54 mL | 2.72 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thurmond The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 2008 PMID: 18172439
- Maintz and Novak Histamine and histamine intolerance. Am.J.Clin.Nutr. 2007 PMID: 17490952
- Hill International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 1997 PMID: 9311023
Product Specific Notices for Histamine dihydrochloride
For research use only
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