HIOC
Tocris Bioscience, part of Bio-Techne | Catalog # 5961
Selective TrkB receptor agonist; neuroprotectant
Key Product Details
Description
Selective TrkB receptor agonist; neuroprotectant
Product Description
HIOC is a selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.Product Specifications
Molecular Weight
301.34
Formula
C16H19N3O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
CAS Number
314054-36-9
PubChem ID
5012758
InChI Key
ZIMKJLALTRLXJO-UHFFFAOYSA-N
SMILES
OC1=CC=C2NC=C(C2=C1)CCNC(C3CCCNC3=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.13 | 100 |
Preparing Stock Solutions
for HIOC
The following data is based on the product molecular weight 301.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.59 mL | 33.19 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shen N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 2012 PMID: 22331903
- Setterholm Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 2015 PMID: 26028783
Product Specific Notices for HIOC
For research use only
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