HEMADO
Tocris Bioscience, part of Bio-Techne | Catalog # 1579
High affinity selective A3 agonist
Key Product Details
Description
High affinity selective A3 agonist
Product Description
HEMADO is a high affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).Product Specifications
Molecular Weight
361.40
Formula
C17H23N5O4
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
2-(1-Hexynyl)-N-methyladenosine
CAS Number
403842-38-6
PubChem ID
10981286
InChI Key
KOCIMZNSNPOGOP-IWCJZZDYSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.14 | 100 | |
| Ethanol | 36.14 | 100 |
Preparing Stock Solutions
for HEMADO
The following data is based on the product molecular weight 361.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.67 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Volpini N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 2002 PMID: 12109910
- Klotz [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 2006 PMID: 17126322
Product Specific Notices for HEMADO
For research use only
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