hCAII Degrader 11
Tocris Bioscience, part of Bio-Techne | Catalog # 7964
Potent human carbonic anhydrase II Degrader (PROTAC®)
Key Product Details
Description
Potent human carbonic anhydrase II Degrader (PROTAC®)
Product Description
hCAII Degrader 11 is a potent human carbonic anhydrase II (hCAII) Degrader (PROTAC®; Dmax = 100% at 5 nM, DC50 = 0.5 nM).PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Sold with kind permission of Professor Cohen and Professor Burkart, Department of Chemistry and Biochemistry, University of California, USA.
Licensing Information
Sold with kind permission of Professor Cohen and Professor BurkartProduct Specifications
Molecular Weight
639.77
Formula
C32H41N5O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-(Aminosulfonyl)-N-[12-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]dodecyl]benzamide
CAS Number
2892306-56-6
PubChem ID
167312395
InChI Key
AZBRPAQQOMDJLZ-UHFFFAOYSA-N
SMILES
O=C(NCCCCCCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(S(=O)(N)=O)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 63.98 | 100 |
Preparing Stock Solutions
for hCAII Degrader 11
The following data is based on the product molecular weight 639.77
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.56 mL | 7.82 mL | 15.63 mL |
| 5 mM | 0.31 mL | 1.56 mL | 3.13 mL |
| 10 mM | 0.16 mL | 0.78 mL | 1.56 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Herin Development of human carbonic anhydrase II heterobifunctional degraders J.Med.Chem. 2023 PMID: 36735827
Product Specific Notices for hCAII Degrader 11
For research use only
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