H 89 dihydrochloride
Catalog # 2910 | Tocris Bioscience a Bio-Techne Brand
Protein kinase A inhibitor
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Key Product Details
Description: | Protein kinase A inhibitor |
Chemical Name: | N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 519.28 |
Citations for H 89 dihydrochloride (46)
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Citations are publications that use Bio-Techne products. Selected citations for H 89 dihydrochloride include:
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Schnabl et al.
(2019)
Opposing Actions of Adrenocorticotropic Hormone and Glucocorticoids on UCP1-Mediated Respiration in Brown Adipocytes.
Front Physiol.
9:1931
PMID: 30705635 -
Jewell et al.
(2019)
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Elife.
8
PMID: 31112131 -
Miteva et al.
(2019)
Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.
J Cell Biol.
2019;
PMID: 31092558 -
Wijerathne et al.
(2019)
Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner.
Korean J Physiol Pharmacol.
23:381
PMID: 31496875 -
Martín-Segura et al.
(2019)
Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.
Front Neurol.
10:675
PMID: 31293510 -
Lopes et al.
(2019)
MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sj�gren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1.
Front Immunol.
10:1335
PMID: 31281310 -
Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
PMID: 31291571 -
Ng
(2018)
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
Cell Signal.
51:59
PMID: 30076967 -
Burdyga et al.
(2018)
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Proc Natl Acad Sci U S A..
115(28):E6497
PMID: 29941564 -
Perkins et al.
(2018)
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Nat.Immunol..
19:1309
PMID: 30397349 -
Cruz et al.
(2018)
Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy.
J Biol Chem.
293:11837
PMID: 29899111 -
Luo
(2017)
β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
Scientific Reports.
7:39905
PMID: 28051147 -
Dai
(2017)
TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice.
Sci Rep.
7:41415
PMID: 28145512 -
Nilsson
(2017)
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers.
Sci Transl Med.
9(415):eaao4307
PMID: 29118262 -
Tozzi et al.
(2017)
DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson�s disease.
Cell Death Dis.
9(2):204
PMID: 29434188 -
Shi et al.
(2017)
Differentiation of human umbilical cord Wharton's jelly-derived mesenchymal stem cells into endometrial cells.
Stem Cell Res Ther.
8:246
PMID: 29096715 -
Guichard et al.
(2017)
Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
PLoS Pathog.
13:e1006603
PMID: 28945820 -
Demeautis et al.
(2017)
Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
Sci Rep.
7:41026
PMID: 28106114 -
Al-Taei et al.
(2017)
Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
Oncoimmunology.
6:e1268308
PMID: 28344879 -
Wu et al.
(2017)
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Nat Cell Biol.
19:1226
PMID: 28945232 -
Acuña et al.
(2016)
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
J Clin Invest.
126:2547
PMID: 27270175 -
Datta et al.
(2016)
Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations.
Mitochondrion.
30:177
PMID: 27497748 -
Brzosko et al.
(2015)
Retroactive modulation of spike timing-dependent plasticity by DA.
Elife.
4
PMID: 26516682 -
Xing et al.
(2015)
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Br J Pharmacol.
9:310
PMID: 26388722 -
Parnell et al.
(2015)
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.
Mol Med Rep.
1853:1749
PMID: 25913012 -
Liu et al.
(2015)
A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells.
Proc Natl Acad Sci U S A.
11:4121
PMID: 25672589 -
Zhu et al.
(2015)
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Cell.
35:621
PMID: 25589756 -
Merino et al.
(2015)
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
PLoS One.
10:e0132884
PMID: 26222156 -
Rioult-Pedotti et al.
(2015)
DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
Cell Death Dis.
10:e0124986
PMID: 25938462 -
Toda and Huganir
(2015)
Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
J Neurosci.
112:6712
PMID: 25964356 -
Chang et al.
(2015)
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Sci Rep.
5:10256
PMID: 26194093 -
Adelfinger et al.
(2014)
GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization.
Biochem Pharmacol.
91:369
PMID: 25065880 -
Chou et al.
(2014)
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells.
PLoS One.
9:e99432
PMID: 24918932 -
Isensee et al.
(2014)
Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.
J Cell Sci.
127:216
PMID: 24190886 -
Liang et al.
(2014)
δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
Biochim Biophys Acta.
171:5417
PMID: 25052197 -
Emery et al.
(2014)
Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.
J Biol Chem.
289:10126
PMID: 24567337 -
Grassin-Delyle et al.
(2013)
The expression and relaxant effect of bitter taste receptors in human bronchi.
Respir Res.
14:134
PMID: 24266887 -
Jahchan et al.
(2013)
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Cancer Discov.
3:1364
PMID: 24078773 -
Sohn et al.
(2013)
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons.
Mol Pharmacol.
152:612
PMID: 23374353 -
Kraynik et al.
(2013)
PDE3 and PDE4 isozyme-selective inhibitors are both required for synergistic activation of brown adipose tissue.
PLoS One.
83:1155
PMID: 23493317 -
Seto et al.
(2013)
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
PLoS One.
8:e66404
PMID: 23799098 -
Santos-Carvalho et al.
(2013)
Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.
Purinergic Signal.
4:e636
PMID: 23681231 -
Lee et al.
(2012)
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Nature.
492:123
PMID: 23143333 -
Meitzen et al.
(2011)
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
J Neurochem.
116:984
PMID: 21143600 -
Higley and Sabatini
(2010)
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Nat Neurosci.
13:958
PMID: 20601948 -
Chung et al.
(2007)
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
J Endocrinol.
194:77
PMID: 17592023
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronal10 μM H-89 for 30 min
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