GW 7647
Tocris Bioscience, part of Bio-Techne | Catalog # 1677
Highly selective, potent PPARα agonist. Orally active
Key Product Details
Description
Highly selective, potent PPARα agonist. Orally active
Product Description
GW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
502.75
Formula
C29H46N2O3S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid
CAS Number
265129-71-3
PubChem ID
3392731
InChI Key
PKNYXWMTHFMHKD-UHFFFAOYSA-N
SMILES
CC(C)(SC1=CC=C(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)C=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.27 | 100 | |
| Ethanol | 12.57 | 25 |
Preparing Stock Solutions
for GW 7647
The following data is based on the product molecular weight 502.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.95 mL | 19.89 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.98 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Paukkeri PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. Br.J.Pharmacol. 2007 PMID: 17891158
- Cunard Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J.Immunol. 2002 PMID: 11884448
- Muoio Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 2002 PMID: 11916905
- Brown Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg.Med.Chem.Lett. 2001 PMID: 11354382
Product Specific Notices for GW 7647
For research use only
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