GW 7647

Name: GW 7647
Brand: Tocris Bioscience
SKU: 1677
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1677

(1)

Citations (63)

COA / SDS

Highly selective, potent PPARα agonist. Orally active

Key Product Details

Description:	Highly selective, potent PPARα agonist. Orally active
Chemical Name:	2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	502.75

View Full Technical Details for GW 7647

Technical Data
Citations / Reviews (1)

Biological Activity for GW 7647

GW 7647 is a potent and highly selective PPARα agonist (EC₅₀ values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administration in vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for GW 7647

GW 7647 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 7647

M. Wt	502.75
Formula	C₂₉H₄₆N₂O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	265129-71-3
PubChem ID	3392731
InChi Key	PKNYXWMTHFMHKD-UHFFFAOYSA-N
Smiles	CC(C)(SC1=CC=C(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 7647

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	12.57	25
	DMSO	50.27	100

Preparing Stock Solutions for GW 7647

The following data is based on the product molecular weight 502.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.95 mL	19.89 mL
5 mM	0.40 mL	1.99 mL	3.98 mL
10 mM	0.20 mL	0.99 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for GW 7647

References are publications that support the biological activity of the product.

Paukkeri PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. Br.J.Pharmacol. 2007 PMID: 17891158
Cunard Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J.Immunol. 2002 PMID: 11884448
Muoio Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 2002 PMID: 11916905
Brown Identification of a subtype selective human PPARα agonist through parallel-array synthesis. Bioorg.Med.Chem.Lett. 2001 PMID: 11354382