GW 583340 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2239
Potent dual EGFR/ErbB2 inhibitor; orally active
Key Product Details
Description
Potent dual EGFR/ErbB2 inhibitor; orally active
Product Description
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.Product Specifications
Molecular Weight
671.03
Formula
C28H25ClFN5O3S2.2HCl
Storage
Desiccate at +4°C
Purity
≥97% (HPLC)
Chemical Name
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
CAS Number
1173023-85-2
PubChem ID
16219404
InChI Key
WIMITXDBYLKRKB-UHFFFAOYSA-N
SMILES
Cl.Cl.CS(=O)(=O)CCNCC1=NC(=CS1)C1=CC=C2N=CN=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 67.1 | 100 with gentle warming |
Preparing Stock Solutions
for GW 583340 dihydrochloride
The following data is based on the product molecular weight 671.03
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.49 mL | 7.45 mL | 14.90 mL |
| 5 mM | 0.30 mL | 1.49 mL | 2.98 mL |
| 10 mM | 0.15 mL | 0.75 mL | 1.49 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gaul Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 2003 PMID: 12639547
Product Specific Notices for GW 583340 dihydrochloride
For research use only
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