GW 280264X
Tocris Bioscience, part of Bio-Techne | Catalog # 7030
Potent ADAM10 and ADAM17 inhibitor
Key Product Details
Description
Potent ADAM10 and ADAM17 inhibitor
Product Description
GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.Product Specifications
Molecular Weight
575.73
Formula
C28H41N5O6S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Phenylmethyl N-[(5S)-5-[[(2R,3S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate
CAS Number
866924-39-2
PubChem ID
91885425
InChI Key
SKJLITFHSZNZMQ-SGNDLWITSA-N
SMILES
CCC[C@H](N(C=O)O)[C@H](C(N[C@H](C(NC1=NC=CS1)=O)CCCCNC(OCC2=CC=CC=C2)=O)=O)CC(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.57 | 100 |
Preparing Stock Solutions
for GW 280264X
The following data is based on the product molecular weight 575.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.74 mL | 8.68 mL | 17.37 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.47 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.74 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sommer ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury Brain Behav.Immun. 2019 PMID: 30851378
- Hundhausen The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 2003 PMID: 12714508
Product Specific Notices for GW 280264X
For research use only
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