GSK2578215A

Name: GSK2578215A
Brand: Tocris Bioscience
SKU: 4629

Tocris Bioscience, part of Bio-Techne | Catalog # 4629

Citations (45)

COA / SDS

Potent, selective LRRK2 inhibitor; brain penetrant

Key Product Details

Description:	Potent, selective LRRK2 inhibitor; brain penetrant
Chemical Name:	5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	399.42

View Full Technical Details for GSK2578215A

Technical Data
Citations

Biological Activity for GSK2578215A

GSK2578215A is a potent LRRK2 inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Displays selectivity for LRRK2 over a panel of 460 other kinases. Blocks Ser910 and Ser935 phosphorylation in vitro and in peripheral tissues in vivo. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Compound Libraries for GSK2578215A

GSK2578215A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK2578215A

M. Wt	399.42
Formula	C₂₄H₁₈FN₃O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1285515-21-0
PubChem ID	68107965
InChi Key	WCIGMFCFPXZRMQ-UHFFFAOYSA-N
Smiles	FC1=NC=CC(C2=CC=C(OCC3=CC=CC=C3)C(C(NC4=CC=CN=C4)=O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK2578215A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.94	100

Preparing Stock Solutions for GSK2578215A

The following data is based on the product molecular weight 399.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.52 mL	25.04 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for GSK2578215A

References are publications that support the biological activity of the product.

Reith GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substituent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg.Med.Chem.Lett. 2012 PMID: 22863203