GSK LSD 1 dihydrochloride

Name: GSK LSD 1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5361

Tocris Bioscience, part of Bio-Techne | Catalog # 5361

Citations (11)

COA / SDS

Potent and selective LSD1 inhibitor

Key Product Details

Description:	Potent and selective LSD1 inhibitor
Chemical Name:	rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	289.24

View Full Technical Details for GSK LSD 1 dihydrochloride

Technical Data
Citations

Biological Activity for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

Compound Libraries for GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK LSD 1 dihydrochloride

M. Wt	289.24
Formula	C₁₄H₂₀N₂.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2102933-95-7
PubChem ID	91663353
InChi Key	PJFZOGMSPBHPNS-WICJZZOFSA-N
Smiles	C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK LSD 1 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.92	100
	DMSO	28.92	100

Preparing Stock Solutions for GSK LSD 1 dihydrochloride

The following data is based on the product molecular weight 289.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.46 mL	17.29 mL	34.57 mL
5 mM	0.69 mL	3.46 mL	6.91 mL
10 mM	0.35 mL	1.73 mL	3.46 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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Product Documents for GSK LSD 1 dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.