GSK LSD 1 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5361
Potent and selective LSD1 inhibitor
Key Product Details
Description
Potent and selective LSD1 inhibitor
Product Description
GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.Product Specifications
Molecular Weight
289.24
Formula
C14H20N2.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride
CAS Number
2102933-95-7
PubChem ID
91663353
InChI Key
PJFZOGMSPBHPNS-WICJZZOFSA-N
SMILES
C1(N[C@@H]2C[C@H]2[C@]3=CC=CC=C3)CCNCC1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.92 | 100 | |
| DMSO | 28.92 | 100 |
Preparing Stock Solutions
for GSK LSD 1 dihydrochloride
The following data is based on the product molecular weight 289.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.29 mL | 34.57 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for GSK LSD 1 dihydrochloride
For research use only
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