GSK'872

Name: GSK'872
Brand: Tocris Bioscience
SKU: 6492
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6492

(1)

Citations (30)

COA / SDS

Potent and selective RIP3 kinase inhibitor

Key Product Details

Description:	Potent and selective RIP3 kinase inhibitor
Chemical Name:	N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	383.49

View Full Technical Details for GSK'872

Technical Data
Citations / Reviews (1)

Biological Activity for GSK'872

GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC₅₀ = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Compound Libraries for GSK'872

GSK'872 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK'872

M. Wt	383.49
Formula	C₁₉H₁₇N₃O₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1346546-69-7
PubChem ID	54674134
InChi Key	ZCDBTQNFAPKACC-UHFFFAOYSA-N
Smiles	CC(S(=O)(C1=CC2=C(N=CC=C2NC3=CC=C4SC=NC4=C3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK'872

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.35	100
	ethanol	38.35	100

Preparing Stock Solutions for GSK'872

The following data is based on the product molecular weight 383.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.30 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for GSK'872

References are publications that support the biological activity of the product.

Mandal RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol.Cell 2014 PMID: 25459880
Kaiser Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J.Biol.Chem. 2013 PMID: 24019532