GSK 6853
Tocris Bioscience, part of Bio-Techne | Catalog # 6198
Potent and selective BRPF1 inhibitor
Key Product Details
Description
Potent and selective BRPF1 inhibitor
Product Description
GSK 6853 is a potent and selective BRPF1 inhibitor. Exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC50 values by TR-FRET are 8.1, 5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively).Negative Control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 6853 probe summary on the SGC website.Product Specifications
Molecular Weight
409.48
Formula
C22H27N5O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide
CAS Number
1910124-24-1
PubChem ID
121232405
InChI Key
FQWDVNSBYDXPIO-CQSZACIVSA-N
SMILES
COC1=C(C(NC2=C(N3CCNC[C@H]3C)C=C4N(C(N(C4=C2)C)=O)C)=O)C=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 40.95 | 100 | |
| DMSO | 40.95 | 100 |
Preparing Stock Solutions
for GSK 6853
The following data is based on the product molecular weight 409.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bamborough GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2016 PMID: 27326325
Product Specific Notices for GSK 6853
For research use only
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