GSK 3787
Tocris Bioscience, part of Bio-Techne | Catalog # 3961
Potent and selective PPARδ antagonist
Key Product Details
Description
Potent and selective PPARδ antagonist
Product Description
GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). Displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5).Product Specifications
Molecular Weight
392.78
Formula
C15H12ClF3N2O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
CAS Number
188591-46-0
PubChem ID
2800647
InChI Key
JFUIMTGOQCQTPF-UHFFFAOYSA-N
SMILES
O=C(C2=CC=C(Cl)C=C2)NCCS(C1=CC=C(C(F)(F)F)C=N1)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.28 | 100 |
Preparing Stock Solutions
for GSK 3787
The following data is based on the product molecular weight 392.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.73 mL | 25.46 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Palkar Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787. Mol.Pharmacol. 2010 PMID: 20516370
- Shearer Identification and characterization of 4-chloro-N(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J.Med.Chem. 2010 PMID: 20128594
Product Specific Notices for GSK 3787
For research use only
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