GSK 2879552

Name: GSK 2879552
Brand: Tocris Bioscience
SKU: 8128

Tocris Bioscience, part of Bio-Techne | Catalog # 8128

COA / SDS

Lysine-Specific Demethylase 1 (LSD1) inhibitor

Key Product Details

Description:	Lysine-Specific Demethylase 1 (LSD1) inhibitor
Chemical Name:	4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	437.41

View Full Technical Details for GSK 2879552

Technical Data
Citations

Biological Activity for GSK 2879552

GSK 2879552 is a selective lysine-specific demethylase 1 (LSD1) inhibitor. When combined with other small molecules (EPZ-5676, N-methyl-d-aspartate and Bay K 8644), GSK 2879552 accelerates maturation of human pluripotent stem cell-derived neurons. GSK 2879552 inhibits the growth of small cell lung carcinoma (SCLC) and AML lines. In vivo, GSK 2879552 (1.5 mg/kg, p.o.) demonstrates tumor growth inhibition in SCLC xenograph mouse models.

Technical Data for GSK 2879552

M. Wt	437.41
Formula	C₂₃H₂₈N₂O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1902123-72-1
PubChem ID	121272425
InChi Key	QEKGSBZKRLHQSZ-VSIGASKDSA-N
Smiles	OC(C(C=C1)=CC=C1CN(CC2)CCC2CN[C@H]3[C@H](C4=CC=CC=C4)C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2879552

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.87	50
	water	8.75	20

Preparing Stock Solutions for GSK 2879552

The following data is based on the product molecular weight 437.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.57 mL	22.86 mL	45.72 mL
2.5 mM	0.91 mL	4.57 mL	9.14 mL
5 mM	0.46 mL	2.29 mL	4.57 mL
25 mM	0.09 mL	0.46 mL	0.91 mL

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References for GSK 2879552

References are publications that support the biological activity of the product.

Mohammad A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 2015 PMID: 26175415
Hergenreder Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat.Biotechnol. 2024 PMID: 38168993