GSK 2879552
Tocris Bioscience, part of Bio-Techne | Catalog # 8128
Lysine-Specific Demethylase 1 (LSD1) inhibitor
Key Product Details
Description
Lysine-Specific Demethylase 1 (LSD1) inhibitor
Product Description
GSK 2879552 is a selective lysine-specific demethylase 1 (LSD1) inhibitor. When combined with other small molecules (EPZ-5676, N-methyl-d-aspartate and Bay K 8644), GSK 2879552 accelerates maturation of human pluripotent stem cell-derived neurons. GSK 2879552 inhibits the growth of small cell lung carcinoma (SCLC) and AML lines. In vivo, GSK 2879552 (1.5 mg/kg, p.o.) demonstrates tumor growth inhibition in SCLC xenograph mouse models.Product Specifications
Molecular Weight
437.41
Formula
C23H28N2O2.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
CAS Number
1902123-72-1
PubChem ID
121272425
InChI Key
QEKGSBZKRLHQSZ-VSIGASKDSA-N
SMILES
OC(C(C=C1)=CC=C1CN(CC2)CCC2CN[C@H]3[C@H](C4=CC=CC=C4)C3)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.75 | 20 | |
| DMSO | 21.87 | 50 |
Preparing Stock Solutions
for GSK 2879552
The following data is based on the product molecular weight 437.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.57 mL | 22.86 mL | 45.72 mL |
| 2.5 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mohammad A DNA hypomethylation signature predicts antitumor activity of LSD1 inhibitors in SCLC. Cancer Cell 2015 PMID: 26175415
- Hergenreder Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat.Biotechnol. 2024 PMID: 38168993
Product Specific Notices for GSK 2879552
For research use only
Loading...
Loading...