GSK 264220A

Name: GSK 264220A
Brand: Tocris Bioscience
SKU: 3752

Tocris Bioscience, part of Bio-Techne | Catalog # 3752

Citations (8)

COA / SDS

Endothelial lipase and lipoprotein lipase inhibitor

Key Product Details

Description:	Endothelial lipase and lipoprotein lipase inhibitor
Chemical Name:	N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Purity:	≥98% (HPLC)
Molecular Weight:	363.43

View Full Technical Details for GSK 264220A

Technical Data
Citations

Biological Activity for GSK 264220A

GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC₅₀ values are 0.13 and 0.10 μM respectively).

Technical Data for GSK 264220A

M. Wt	363.43
Formula	C₁₇H₂₁N₃O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	685506-42-7
PubChem ID	2810413
InChi Key	LVOVQRPAMXCXTM-UHFFFAOYSA-N
Smiles	CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 264220A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.34	100
	ethanol	3.63	10

Preparing Stock Solutions for GSK 264220A

The following data is based on the product molecular weight 363.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.76 mL	27.52 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
10 mM	0.28 mL	1.38 mL	2.75 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for GSK 264220A

References are publications that support the biological activity of the product.

Goodman Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts.
Keller A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 2008 PMID: 18566479