GSK 264220A
Tocris Bioscience, part of Bio-Techne | Catalog # 3752
Endothelial lipase and lipoprotein lipase inhibitor
Key Product Details
Description
Endothelial lipase and lipoprotein lipase inhibitor
Product Description
GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).Product Specifications
Molecular Weight
363.43
Formula
C17H21N3O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
CAS Number
685506-42-7
PubChem ID
2810413
InChI Key
LVOVQRPAMXCXTM-UHFFFAOYSA-N
SMILES
CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.34 | 100 | |
| Ethanol | 3.63 | 10 |
Preparing Stock Solutions
for GSK 264220A
The following data is based on the product molecular weight 363.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.76 mL | 27.52 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Goodman Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts.
- Keller A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 2008 PMID: 18566479
Product Specific Notices for GSK 264220A
For research use only
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