GS 6201

Tocris Bioscience, part of Bio-Techne | Catalog # 4727

COA / SDS

Selective A2B antagonist

Key Product Details

Description:	Selective A_2B antagonist
Alternative Names:	CVT 6883
Chemical Name:	3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	446.43

View Full Technical Details for GS 6201

Technical Data
Citations

Biological Activity for GS 6201

GS 6201 is a selective antagonist of adenosine A_2B receptors (K_i values are 22, 1070, 1940 and 3280 nM for human A_2B, A₃, A₁ and A_2A receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.

Compound Libraries for GS 6201

GS 6201 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GS 6201

M. Wt	446.43
Formula	C₂₁H₂₁F₃N₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	752222-83-6
PubChem ID	11270783
InChi Key	KOYXXLLNCXWUNF-UHFFFAOYSA-N
Smiles	O=C(N(CC)C2=C1NC(C3=CN(CC4=CC=CC(C(F)(F)F)=C4)N=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GS 6201

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.23	5

Preparing Stock Solutions for GS 6201

The following data is based on the product molecular weight 446.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	44.80 mL	224.00 mL	448.00 mL
0.25 mM	8.96 mL	44.80 mL	89.60 mL
0.5 mM	4.48 mL	22.40 mL	44.80 mL
2.5 mM	0.90 mL	4.48 mL	8.96 mL

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References for GS 6201

References are publications that support the biological activity of the product.

Toldo GS-6201, a selective blocker of the A_2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J.Pharmacol.Exp.Ther. 2012 PMID: 22923737
Mustafa Effect of a specific and selective A_2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J.Pharmacol.Exp.Ther. 2007 PMID: 17159162
Elzein Discovery of a novel A_2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. J.Med.Chem. 2008 PMID: 18321039