GRL 0617

Tocris Bioscience, part of Bio-Techne | Catalog # 7280

Coronavirus PLpro inhibitor
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Key Product Details

Description

Coronavirus PLpro inhibitor

View all Papain-like Protease Inhibitors »

Product Description

GRL 0617 is a coronavirus papain-like protease (Plpro) inhibitor (IC50 values are 0.6 and 0.8 μM for SARS-COV and SARS-CoV-2 PLpro, respectively). Inhibits deubiquitination activity of SARS-CoV PLpro. Displays no inhibition of human deubiquitinating enzymes. Improves cell viability following SARS-CoV infection. Inhibits SARS-CoV-2 viral replication and induces antiviral immune signaling pathways following SARS-CoV-2 infection in CaCo-2 cells.

Product Specifications

Molecular Weight

304.39

Formula

C20H20N2O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide

CAS Number

1093070-16-6

PubChem ID

24941262

InChI Key

UVERBUNNCOKGNZ-CQSZACIVSA-N

SMILES

C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(N)=C3)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.44 100
Ethanol 30.44 100

Preparing Stock Solutions for GRL 0617

The following data is based on the product molecular weight 304.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.85 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for GRL 0617

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GRL 0617

For research use only

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