GR 64349
Tocris Bioscience, part of Bio-Techne | Catalog # 1668
Potent, selective NK2 agonist
Product Description
GR 64349 is a potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
921.12
Formula
C42H68N10O11S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
137593-52-3
PubChem ID
5311135
InChI Key
HVUNRXRFMQDMBO-BPZYSUIOSA-N
SMILES
[H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NC1CCN([C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Chizh Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br.J.Pharmacol. 1995 PMID: 7582497
- Deal Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J.Med.Chem. 1992 PMID: 1331460
- Chang Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 2000 PMID: 10871306
Product Specific Notices for GR 64349
For research use only
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