GR 144053 trihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1263
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
Key Product Details
Description
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
Product Description
GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.Product Specifications
Molecular Weight
454.83
Formula
C18H27N5O2.3HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride
CAS Number
1215333-48-4
PubChem ID
107895
InChI Key
GFZHNFOGCMEYTA-UHFFFAOYSA-N
SMILES
Cl.Cl.Cl.NC(=N)C1=CC=C(C=C1)N1CCN(CC1)C1CCN(CC(O)=O)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.48 | 100 |
Preparing Stock Solutions
for GR 144053 trihydrochloride
The following data is based on the product molecular weight 454.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 10.99 mL | 21.99 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.40 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Matsuno GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 1997 PMID: 9480031
- Matsuno Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 1999 PMID: 10455258
- Eldred Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 1994 PMID: 7966149
Product Specific Notices for GR 144053 trihydrochloride
For research use only
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