GR 125487 sulfamate
Tocris Bioscience, part of Bio-Techne | Catalog # 1658
Potent and selective 5-HT4 antagonist; active in vivo
Key Product Details
Description
Potent and selective 5-HT4 antagonist; active in vivo
Product Description
GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
524.58
Formula
C19H26FN3O5S.H2NSO3H
Storage
Desiccate at RT
Purity
≥97% (HPLC)
Chemical Name
5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate
CAS Number
859502-43-5
PubChem ID
6604955
InChI Key
VQJFDBXITIOGJM-UHFFFAOYSA-N
SMILES
NS(O)(=O)=O.COC1=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C2=CC(F)=CC=C2N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.27 | 10 with gentle warming |
Preparing Stock Solutions
for GR 125487 sulfamate
The following data is based on the product molecular weight 524.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.06 mL | 95.31 mL | 190.63 mL |
| 0.5 mM | 3.81 mL | 19.06 mL | 38.13 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.06 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Horikoshi Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisp. in Suncus murinus. Jpn.J.Pharmacol. 2001 PMID: 11243577
- Schiavi Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 1994 PMID: 7984293
- Galeotti Role of 5-HT4 receptors in the mouse passive avoidance test. J.Pharmacol.Exp.Ther. 1998 PMID: 9732367
Product Specific Notices for GR 125487 sulfamate
For research use only
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