GR 113808

Tocris Bioscience, part of Bio-Techne | Catalog # 1322

Potent and selective 5-HT4 antagonist
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1322/10
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Key Product Details

Description

Potent and selective 5-HT4 antagonist

View all 5-HT4 Receptor Antagonists »

Product Description

GR 113808 is a potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications

Molecular Weight

393.50

Formula

C19H27N3O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester

CAS Number

144625-51-4

PubChem ID

119376

InChI Key

MOZPSIXKYJUTKI-UHFFFAOYSA-N

SMILES

CN1C=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 9.84 25

Preparing Stock Solutions for GR 113808

The following data is based on the product molecular weight 393.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.17 mL 50.83 mL 101.65 mL
1.25 mM 2.03 mL 10.17 mL 20.33 mL
2.5 mM 1.02 mL 5.08 mL 10.17 mL
12.5 mM 0.20 mL 1.02 mL 2.03 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for GR 113808

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GR 113808

For research use only

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