Go 6983

Product Description

Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC₅₀ values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

Solubility

Preparing Stock Solutions for Go 6983

The following data is based on the product molecular weight 442.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.52 mL	22.60 mL	45.20 mL
2.5 mM	0.90 mL	4.52 mL	9.04 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gafni Derivation of novel human ground state naive pluripotent stem cells. Nature 2013 PMID: 24172903
• Peterman Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 2004 PMID: 15071351
• Young Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 2005 PMID: 16252018
• Gschwendt Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 1996 PMID: 8772178