GNF 2

Name: GNF 2
Brand: Tocris Bioscience
SKU: 4399

Tocris Bioscience a Bio-Techne Brand

Catalog # 4399

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Key Product Details

Description:	Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Chemical Name:	3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	374.32

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Biological Activity for GNF 2

GNF 2 is an allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC₅₀ = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

Technical Data for GNF 2

M. Wt	374.32
Formula	C₁₈H₁₃F₃N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	778270-11-4
PubChem ID	5311510
InChi Key	WEVYNIUIFUYDGI-UHFFFAOYSA-N
Smiles	NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GNF 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.43	100
	ethanol	18.72	50

Preparing Stock Solutions for GNF 2

The following data is based on the product molecular weight 374.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.36 mL	26.72 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for GNF 2

References are publications that support the biological activity of the product.

Zhang Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 2010 PMID: 20072125
Adrián Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2006 PMID: 16415863
Ohren & Sebolt-Leopold Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2006 PMID: 16421581

Citations for GNF 2

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GNF 2

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Biological Activity for GNF 2

Technical Data for GNF 2

Solubility for GNF 2

Preparing Stock Solutions for GNF 2

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GNF 2

Citations for GNF 2

Product Documents for GNF 2

COA

Certificate of Analysis

SDS

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