GNF 2
Tocris Bioscience, part of Bio-Techne | Catalog # 4399
Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Discontinued Product
4399 has been discontinued.
View all Abl Kinase Inhibitors products.
Key Product Details
Description
Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
Product Description
GNF 2 is an allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.Product Specifications
Molecular Weight
374.32
Formula
C18H13F3N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
CAS Number
778270-11-4
PubChem ID
5311510
InChI Key
WEVYNIUIFUYDGI-UHFFFAOYSA-N
SMILES
NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.43 | 100 | |
| Ethanol | 18.72 | 50 |
Preparing Stock Solutions
for GNF 2
The following data is based on the product molecular weight 374.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.36 mL | 26.72 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Adrián Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2006 PMID: 16415863
- Ohren & Sebolt-Leopold Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2006 PMID: 16421581
- Zhang Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 2010 PMID: 20072125
Product Specific Notices for GNF 2
For research use only
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