GM 6001
Tocris Bioscience, part of Bio-Techne | Catalog # 2983
Broad spectrum MMP inhibitor
Key Product Details
Description
Broad spectrum MMP inhibitor
Alternative Names
Galardin,Ilomastat
Product Description
GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM).Product Specifications
Molecular Weight
388.46
Formula
C20H28N4O4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
CAS Number
142880-36-2
PubChem ID
132519
InChI Key
NITYDPDXAAFEIT-DYVFJYSZSA-N
SMILES
O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.85 | 100 |
Preparing Stock Solutions
for GM 6001
The following data is based on the product molecular weight 388.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.87 mL | 25.74 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Grobelny Inhibition of skin fibroblast Col. , thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 1992 PMID: 1322694
- Chao Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 2007 PMID: 17678888
- Shichi Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 2011 PMID: 21602423
Product Specific Notices for GM 6001
For research use only
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