Use of glycine as NMDA receptor co-agonist
Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.
For experiments with NMDA receptors use of D-Serine is sometimes better.