Givinostat hydrochloride

Name: Givinostat hydrochloride
Brand: Tocris Bioscience
SKU: 6249

Tocris Bioscience a Bio-Techne Brand

Catalog # 6249

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Key Product Details

Description:	Histone deacetylase inhibitor
Alternative Names:	ITF 2357
Chemical Name:	[6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	457.95

View Full Technical Details for Givinostat hydrochloride

Biological Activity for Givinostat hydrochloride

Givinostat hydrochloride is a histone deacetylase (HDAC) inhibitor (IC₅₀ = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.

Compound Libraries for Givinostat hydrochloride

Givinostat hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Givinostat hydrochloride

M. Wt	457.95
Formula	C₂₄H₂₇N₃O₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	199657-29-9
PubChem ID	10095659
InChi Key	QKSGNWJOQMSBEP-UHFFFAOYSA-N
Smiles	CCN(CC1=CC2=C(C=C(C=C2)COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C1)CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Givinostat hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.8	100

Preparing Stock Solutions for Givinostat hydrochloride

The following data is based on the product molecular weight 457.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.92 mL	21.84 mL
5 mM	0.44 mL	2.18 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Givinostat hydrochloride

References are publications that support the biological activity of the product.

Shein Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB.J. 2009 PMID: 19723705
Leoni The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol.Med. 2005 PMID: 16557334

Citations for Givinostat hydrochloride

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