Gilteritinib
Tocris Bioscience, part of Bio-Techne | Catalog # 7891
Potent FLT3 inhibitor; also potently inhibits AXL
Key Product Details
Description
Potent FLT3 inhibitor; also potently inhibits AXL
Product Description
Gilteritinib is a potent Fms-like tyrosine kinase 3 (FLT3) and AXL inhibitor (IC50 = 0.29 nM and 0.73 nM, for FLT3 and AXL, respectively). In vivo, Gilteritinib reduces tumor growth and improves survival in xenograft and intra-bone marrow transplantation models of FLT3 mutated acute myeloid leukemia. Gilteritinib is orally bioavailable.Product Specifications
Molecular Weight
552.71
Formula
C29H44N8O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
CAS Number
1254053-43-4
InChI Key
GYQYAJJFPNQOOW-UHFFFAOYSA-N
SMILES
O=C(N)C=1N=C(C(=NC1NC2=CC=C(C(OC)=C2)N3CCC(N4CCN(C)CC4)CC3)NC5CCOCC5)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.53 | 10 |
Preparing Stock Solutions
for Gilteritinib
The following data is based on the product molecular weight 552.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.09 mL | 90.46 mL | 180.93 mL |
| 0.5 mM | 3.62 mL | 18.09 mL | 36.19 mL |
| 1 mM | 1.81 mL | 9.05 mL | 18.09 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mori Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest.New Drugs 2017 PMID: 28516360
Product Specific Notices for Gilteritinib
For research use only
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