GI 530159

Tocris Bioscience, part of Bio-Techne | Catalog # 6689

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
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Key Product Details

Description

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator

View all Two-P Potassium Channels Activators »

Product Description

GI 530159 is a TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.

Product Specifications

Molecular Weight

518.45

Formula

C27H20F6N2O2

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]

CAS Number

69563-88-8

PubChem ID

94652

InChI Key

HHLMWQDRYZAENA-UHFFFAOYSA-N

SMILES

NC1=CC=C(C=C1)OC2=CC=C(C(C(F)(F)F)(C(F)(F)F)C3=CC=C(C=C3)OC4=CC=C(C=C4)N)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.84 100
Ethanol 25.92 50

Preparing Stock Solutions for GI 530159

The following data is based on the product molecular weight 518.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.64 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for GI 530159

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GI 530159

For research use only

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