GGsTop

Name: GGsTop
Brand: Tocris Bioscience
SKU: 4452

Tocris Bioscience, part of Bio-Techne | Catalog # 4452

Citations (15)

COA / SDS

Inhibitor of γ-glutamyl transpeptidase (GGT)

Key Product Details

Description:	Inhibitor of γ-glutamyl transpeptidase (GGT)
Chemical Name:	3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
Purity:	≥95% (HPLC)
Molecular Weight:	331.26

View Full Technical Details for GGsTop

Technical Data
Citations

Biological Activity for GGsTop

GGsTop is a selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.

Technical Data for GGsTop

M. Wt	331.26
Formula	C₁₃H₁₈NO₇P
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	926281-37-0
PubChem ID	23582776
InChi Key	NTFPDEDRMYYPAC-UHFFFAOYSA-N
Smiles	NC(C(O)=O)CCP(OC1=CC=CC(CC(O)=O)=C1)(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GGsTop

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.63	20
	DMSO	16.56	50

Preparing Stock Solutions for GGsTop

The following data is based on the product molecular weight 331.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.04 mL	30.19 mL	60.38 mL
2.5 mM	1.21 mL	6.04 mL	12.08 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
25 mM	0.12 mL	0.60 mL	1.21 mL

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References for GGsTop

References are publications that support the biological activity of the product.

Yamamoto Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 2011 PMID: 21937737
Han Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 2007 PMID: 17260973