GC 1

Name: GC 1
Brand: Tocris Bioscience
SKU: 4554

Tocris Bioscience, part of Bio-Techne | Catalog # 4554

Citations (21)

COA / SDS

High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic

Key Product Details

Description:	High affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic
Alternative Names:	Sobetirome
Chemical Name:	2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	328.4

View Full Technical Details for GC 1

Technical Data
Citations

Biological Activity for GC 1

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (K_D values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T₃ in vitro at TRα₁ and TRβ₁ receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

Compound Libraries for GC 1

GC 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GC 1

M. Wt	328.4
Formula	C₂₀H₂₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	211110-63-3
PubChem ID	9862248
InChi Key	QNAZTOHXCZPOSA-UHFFFAOYSA-N
Smiles	CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GC 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.42	50
	ethanol	16.42	50

Preparing Stock Solutions for GC 1

The following data is based on the product molecular weight 328.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.09 mL	30.45 mL	60.90 mL
2.5 mM	1.22 mL	6.09 mL	12.18 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
25 mM	0.12 mL	0.61 mL	1.22 mL

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References for GC 1

References are publications that support the biological activity of the product.

Johansson Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 2005 PMID: 16006512
Columbano The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 2006 PMID: 16574785
Chiellini A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 1998 PMID: 9653548