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Key Product Details
Description: | Selective DA uptake inhibitor; also σ ligand |
Chemical Name: | 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 523.49 |
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Citations (12)
Citations are publications that use Bio-Techne products. Selected citations for GBR 12909 dihydrochloride include:
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Beerepoot et al.
(2016)
Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells.
J Biol Chem.
291:22053
PMID: 27555326 -
Kim et al.
(2015)
Spinal DArgic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
J Neurosci.
35:6307
PMID: 25904784 -
Wang et al.
(2014)
Enhanced synthesis and release of DA in transgenic mice with gain-of-function α6* nAChRs.
J Neurochem.
129:315
PMID: 24266758 -
Squillace et al.
(2014)
Dysfunctional DArgic neurotransmission in asocial BTBR mice.
Transl Psychiatry.
4:e427
PMID: 25136890 -
Patel et al.
(2012)
Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.
PLoS One.
7:e41623
PMID: 22911828 -
Hutchinson et al.
(2012)
Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
J Neurosci.
37:321
PMID: 21956448 -
Koprich et al.
(2011)
Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.
PLoS One.
6:e17698
PMID: 21408191 -
Navaroli et al.
(2011)
The plasma membrane-associated GTPase Rin interacts with the DA transporter and is required for protein kinase C-regulated DA transporter trafficking.
J Neurosci.
31:13758
PMID: 21957239 -
Koprich et al.
(2010)
Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pat
Mol Neurodegener.
5:43
PMID: 21029459 -
Abdallah et al.
(2009)
Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal DA pathway function.
Br J Pharmacol.
29:8156
PMID: 19553455 -
Costa et al.
(2008)
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
J Neurosci.
28:8040
PMID: 18685029 -
Visanji et al.
(2008)
PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.
FASEB J.
22:2488
PMID: 18364399
There are no citations that match your criteria.
Customer Reviews (1)
Customer Images
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Species: MouseAssay Type: Ex VivoGBR-12909 (300 nM) was used as a DAT blocker in slice voltametry experiments. It's difficult to get into solution. Just use some warming.
There are no reviews that match your criteria.