GBR 12783 dihydrochloride

Name: GBR 12783 dihydrochloride
Brand: tocris
SKU: 0513
Rating: 4 (1 reviews)

Catalog # 0513

Citations (4)

(1)

Datasheet / COA / SDS

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Key Product Details

Description:	Potent and selective DA uptake inhibitor
Chemical Name:	1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	485.5

View Full Technical Details for GBR 12783 dihydrochloride

Biological Activity

A very potent and selective inhibitor of dopamine uptake (IC₅₀ for inhibition of [³H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

Technical Data

M. Wt	485.5
Formula	C₂₈H₃₂N₂O.2HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	67469-75-4
PubChem ID	24744862
InChi Key	HJDXBLLTRMCYNC-JFXLULTRSA-N
Smiles	Cl[H].Cl[H].C(CN1CCN(C\C=C\C2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.86	10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 485.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.60 mL	102.99 mL	205.97 mL
0.5 mM	4.12 mL	20.60 mL	41.19 mL
1 mM	2.06 mL	10.30 mL	20.60 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

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References

References are publications that support the biological activity of the product.

Bonnet and Constentin GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 1986 PMID: 3754516
Do-Rego Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA. J.Neurochem. 1999 PMID: 9886093
Giros Cloning, pharmacological characterization and chromosome assignment of the human DA transporter. Mol.Pharmacol. 1992 PMID: 1406597
Vaugeois In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [³H]GBR 12783. Eur.J.Pharmacol. 1992 PMID: 1350989

Citations (4)

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Citations are publications that use Bio-Techne products. Selected citations for GBR 12783 dihydrochloride include:

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 23(13):3852
PMID: 29949769
Masi et al. (2013) MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons. Br J Pharmacol. 169:130
PMID: 23323755
Ferraro et al. (2012) A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. Neuropsychopharmacology. 37:1856
PMID: 22453136
Ferreira et al. (2012) Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. J Pharmacol Exp Ther. 61:219
PMID: 22609378

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Inhibition of Synaptic Transmission in the VP

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

DAT blocker GBR12783 (1 μΜ)

PMID: 29949769

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Product Datasheets

COA

Certificate of Analysis

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GBR 12783 dihydrochloride

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Citations (4)

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Inhibition of Synaptic Transmission in the VP

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Certificate of Analysis

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