Gavestinel

Tocris Bioscience, part of Bio-Techne | Catalog # 2348

Potent and selective NMDA antagonist; acts at the glycine site
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Key Product Details

Description

Potent and selective NMDA antagonist; acts at the glycine site

Alternative Names

GV 150526A

View all NMDA Receptor Antagonists »

Product Description

Gavestinel is a highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications

Molecular Weight

397.19

Formula

C18H11Cl2N2O3Na

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt

CAS Number

153436-38-5

PubChem ID

16759177

InChI Key

GRSDSTMFQHAESM-UHDJGPCESA-M

SMILES

[Na+].[O-]C(=O)C1=C(\C=C\C(=O)NC2=CC=CC=C2)C2=C(N1)C=C(Cl)C=C2Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.89 40

Preparing Stock Solutions for Gavestinel

The following data is based on the product molecular weight 397.19

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 6.29 mL 31.47 mL 62.94 mL
2 mM 1.26 mL 6.29 mL 12.59 mL
4 mM 0.63 mL 3.15 mL 6.29 mL
20 mM 0.13 mL 0.63 mL 1.26 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Gavestinel

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Gavestinel

For research use only

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