Gap19

Tocris Bioscience, part of Bio-Techne | Catalog # 5353

Cx43 hemichannel blocker
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Key Product Details

Description

Cx43 hemichannel blocker

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Product Description

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Product Specifications

Molecular Weight

1161.45

Formula

C55H96N14O13

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1507930-57-5

PubChem ID

91691126

InChI Key

IEAKEKFIXUZWEH-PKMKMBMKSA-N

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for Gap19

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Gap19

For research use only

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