Gap 27

Name: Gap 27
Brand: Tocris Bioscience
SKU: 1476

Tocris Bioscience, part of Bio-Techne | Catalog # 1476

Citations (34)

COA / SDS

Selective gap junction blocker

Key Product Details

Description:	Selective gap junction blocker
Purity:	≥95% (HPLC)
Molecular Weight:	1304.55

View Full Technical Details for Gap 27

Technical Data
Citations

Biological Activity for Gap 27

Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K⁺-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Technical Data for Gap 27

M. Wt	1304.55
Formula	C₆₀H₁₀₁N₁₅O₁₇
Single Letter Sequence	SRPTEKTIFII
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	198284-64-9
PubChem ID	9920128
InChi Key	SXRAPDIXXYFGJG-MDAHIHQXSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gap 27

Solubility

Soluble to 1mg/ml in water

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References for Gap 27

References are publications that support the biological activity of the product.

Ko Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 2000 PMID: 10898726
Richards Suppression of K⁺-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 2001 PMID: 11522590
Chaytor Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 1998 PMID: 9508817