GANT 61

Tocris Bioscience, part of Bio-Techne | Catalog # 3191

GLI antagonist; inhibits Hedgehog (Hh) signaling
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Key Product Details

Description

GLI antagonist; inhibits Hedgehog (Hh) signaling

View all Hedgehog Signaling Inhibitors »

Product Description

GANT 61 is a GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

Product Specifications

Molecular Weight

429.61

Formula

C27H35N5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

CAS Number

500579-04-4

PubChem ID

421610

InChI Key

KVQOGDQTWWCZFX-UHFFFAOYSA-N

SMILES

CN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.48 50
Ethanol 42.96 100

Preparing Stock Solutions for GANT 61

The following data is based on the product molecular weight 429.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GANT 61

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GANT 61

For research use only

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