Key Product Details
Description: | GLI antagonist; inhibits Hedgehog (Hh) signaling |
Chemical Name: | 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 429.61 |
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Citations for GANT 61 (5)
Citations are publications that use Bio-Techne products. Selected citations for GANT 61 include:
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Calcaterra et al.
(2018)
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.
J Enzyme Inhib Med Chem.
33:349
PMID: 29338454 -
Oladapo
(2017)
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Cancer Lett.
411:136
PMID: 28965853 -
Lim et al.
(2015)
Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.
Oncotarget.
6:1519
PMID: 25544756 -
Todd and Fischer
(2015)
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina.
Development.
142:2610
PMID: 26116667 -
Wellbrock et al.
(2015)
Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.
Clin Cancer Res.
21:2388
PMID: 25745035
There are no citations that match your criteria.