Galanthamine hydrobromide

Name: Galanthamine hydrobromide
Brand: Tocris Bioscience
SKU: 0686

Catalog # 0686

Citations (1)

COA / SDS

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Key Product Details

Description:	Cholinesterase inhibitor
Chemical Name:	4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	368.27

View Full Technical Details for Galanthamine hydrobromide

Biological Activity

Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC₅₀ = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Technical Data

M. Wt	368.27
Formula	C₁₇H₂₁NO₃.HBr
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1953-04-4
PubChem ID	121587
InChi Key	QORVDGQLPPAFRS-XPSHAMGMSA-N
Smiles	O[C@H]1C=C[C@]([C@]2=C(O4)C(OC)=CC=C2CN(CC3)C)3[C@@H]4C1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.37	20 with gentle warming
	water	7.37	20

Preparing Stock Solutions

The following data is based on the product molecular weight 368.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.58 mL	67.88 mL	135.77 mL
1 mM	2.72 mL	13.58 mL	27.15 mL
2 mM	1.36 mL	6.79 mL	13.58 mL
10 mM	0.27 mL	1.36 mL	2.72 mL

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References

References are publications that support the biological activity of the product.

Arias Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 2004 PMID: 14654102
Samochocki Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12649296
Capsoni Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12205295
Harvey The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 1995 PMID: 8604434
Sweeney Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 1989 PMID: 2626444

Citations for Galanthamine hydrobromide (1)

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Citations are publications that use Bio-Techne products. Selected citations for Galanthamine hydrobromide include:

Souza et al. (2012) Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome. Sci Rep. 1:137
PMID: 22355654

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