Key Product Details
Description: | High affinity and selective GPER antagonist |
Chemical Name: | (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 370.24 |
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Citations for G-15 (21)
Citations are publications that use Bio-Techne products. Selected citations for G-15 include:
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Bian et al.
(2019)
17β-E2 Regulates Glucose Metabolism and Ins. Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway.
Front Endocrinol (Lausanne).
10:531
PMID: 31447779 -
Loiola et al.
(2019)
Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1.
Front Endocrinol (Lausanne).
10:420
PMID: 31297095 -
Cortes et al.
(2019)
TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Oncogene.
38:2910
PMID: 30575816 -
Cortes et al.
(2019)
TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
EMBO Rep.
20
PMID: 30538116 -
Cortes et al.
(2019)
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
EMBO Rep.
20
PMID: 30538117 -
Caballero et al.
(2017)
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.
Sci Rep.
7:40981
PMID: 28112187 -
Treen et al.
(2016)
Divergent regulation of ER and kiss genes by 17�-OE in hypothalamic ARC versus AVPV models.
Mol.Endocrinol..
30:217
PMID: 26726951 -
Bugel et al.
(2016)
Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.
Toxicol Appl Pharmacol.
296:31
PMID: 26908177 -
Kanageswaran et al.
(2016)
Modulatory Effects of Sex Steroids Progesterone and OE on Odorant Evoked Responses in Olfactory Receptor Neurons.
PLoS One.
11:e0159640
PMID: 27494699 -
Bertrand et al.
(2015)
HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol.
Mol Med Rep.
6:894
PMID: 26441850 -
Chen et al.
(2015)
G-protein-coupled receptor 30-mediated antiapoptotic effect of estrogen on spinal motor neurons following injury and its underlying mechanisms.
Sci Rep.
12:1733
PMID: 25872489 -
Villa et al.
(2015)
Estrogen accelerates the resolution of inflammation in macrophagic cells.
Breast Cancer Res.
5:15224
PMID: 26477569 -
Yuan et al.
(2015)
Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamox. resistance through cancer-associated fibroblast-derived fibronectin and
PLoS One.
17:69
PMID: 25990368 -
Carnesecchi et al.
(2015)
Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30.
Int J Mol Sci.
10:e0120672
PMID: 25781607 -
Mazzuca et al.
(2015)
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
J Pharmacol Exp Ther.
352:291
PMID: 25472954 -
Koong and Watson
(2014)
Direct OE and diethylstilbestrol actions on early- versus late-stage prostate cancer cells.
Prostate.
74:1589
PMID: 25213831 -
An et al.
(2014)
Estrogen rapidly enhances incisional pain of ovariectomized rats primarily through the G protein-coupled estrogen receptor.
J Neurosci.
15:10479
PMID: 24921706 -
Sandner et al.
(2014)
Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility.
Andrology.
2:695
PMID: 25052196 -
Francesco et al.
(2014)
GPER mediates activation of HIF1α/VEGF signaling by estrogens.
Cancer Res.
74:4053
PMID: 24894716 -
Duncan et al.
(2012)
2-MethoxyOE inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.
Proc Natl Acad Sci U S A.
109:21034
PMID: 23213242 -
Liu et al.
(2011)
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal mor. antinociception.
J Neurosci.
31:11836
PMID: 21849544
There are no citations that match your criteria.
Customer Reviews for G-15 (1)
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Species: RatAssay Type: In VitroCell Line/Tissue: endothelial cell primary culturei used to blocked the gper30 receptor in endothelial cell culture to quantificate if estradiol and metabolites induce mobilization of calciumI order this product from chile
There are no reviews that match your criteria.