FzM1.8
Tocris Bioscience, part of Bio-Techne | Catalog # 6961
Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness
Key Product Details
Description
Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness
Product Description
FzM1.8 is a frizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.Product Specifications
Molecular Weight
322.32
Formula
C18H14N2O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
CAS Number
2204290-85-5
PubChem ID
137553171
InChI Key
XGNNCRZDDAJBFU-UHFFFAOYSA-N
SMILES
OC(=O)C1=CC(O)=CC(NC(=O)NC2=CC3=C(C=CC=C3)C=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.23 | 100 |
Preparing Stock Solutions
for FzM1.8
The following data is based on the product molecular weight 322.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.51 mL | 31.03 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Riccio A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 2018 PMID: 29293331
Product Specific Notices for FzM1.8
For research use only
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