Furosemide
Tocris Bioscience, part of Bio-Techne | Catalog # 3109
Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist
Key Product Details
Description
Na+/2Cl-/K+ (NKCC) symporter inhibitor; also GABAA antagonist
Product Description
Furosemide is a loop diuretic that inhibits the Na+/2Cl-/K+ (NKCC) symporter. Also acts as a non-competitive antagonist at GABAA receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.Product Specifications
Molecular Weight
330.74
Formula
C12H11ClN2O5S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
CAS Number
54-31-9
PubChem ID
3440
InChI Key
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
SMILES
ClC1=CC(NCC2=CC=CO2)=C(C(O)=O)C=C1S(=O)(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.07 | 100 |
Preparing Stock Solutions
for Furosemide
The following data is based on the product molecular weight 330.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.12 mL | 30.24 mL |
| 5 mM | 0.60 mL | 3.02 mL | 6.05 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gutschmidt Anticonvulsant actions of Furos. in vitro. Neuroscience 1999 PMID: 10391452
- Thompson Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by Furos.. Mol.Pharmacol. 1999 PMID: 10347239
Product Specific Notices for Furosemide
For research use only
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