FR 171113

Name: FR 171113
Brand: Tocris Bioscience
SKU: 3643
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3643

(1)

Citations (5)

COA / SDS

PAR1 antagonist

Key Product Details

Description:	PAR₁ antagonist
Chemical Name:	2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	469.73

View Full Technical Details for FR 171113

Technical Data
Citations / Reviews (1)

Biological Activity for FR 171113

FR 171113 is a protease-activated receptor 1 (PAR₁) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC₅₀ = 2.5 μM) with no effect on coagulation time.

Technical Data for FR 171113

M. Wt	469.73
Formula	C₁₉H₁₁Cl₃N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	173904-50-2
PubChem ID	25015749
InChi Key	SDGLYCKTPKZBGI-DALCUZTNSA-N
Smiles	O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FR 171113

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.7	10

Preparing Stock Solutions for FR 171113

The following data is based on the product molecular weight 469.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.29 mL	106.44 mL	212.89 mL
0.5 mM	4.26 mL	21.29 mL	42.58 mL
1 mM	2.13 mL	10.64 mL	21.29 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

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Reconstitution Calculator

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References for FR 171113

References are publications that support the biological activity of the product.

Kato Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 2003 PMID: 12892834
Kato In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 1999 PMID: 10611442