Fluvastatin sodium

Name: Fluvastatin sodium
Brand: Tocris Bioscience
SKU: 3309

Tocris Bioscience a Bio-Techne Brand

Catalog # 3309

Citations (5)

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Key Product Details

Description:	Potent HMG-CoA reductase inhibitor
Chemical Name:	(±)-(3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	433.45

View Full Technical Details for Fluvastatin sodium

Biological Activity for Fluvastatin sodium

Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC₅₀ = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC₅₀ = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.

Compound Libraries for Fluvastatin sodium

Fluvastatin sodium is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fluvastatin sodium

M. Wt	433.45
Formula	C₂₄H₂₅FNNaO₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	93957-55-2
PubChem ID	76969265
InChi Key	BNZHURJBOKXWJX-ZKBIPVLYSA-L
Smiles	[Na+].[Na+].CC(C)N1C(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2.CC(C)N1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fluvastatin sodium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	10.84	25
	DMSO	43.34	100

Preparing Stock Solutions for Fluvastatin sodium

The following data is based on the product molecular weight 433.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.54 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL
10 mM	0.23 mL	1.15 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Fluvastatin sodium

References are publications that support the biological activity of the product.

Turner Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 2007 PMID: 18049315
Yamamoto Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 2001 PMID: 11273020
Dansette HMG-CoA reductase activity in human liver microsomes: comparative inhibition by STAT. Exp.Toxicol.Pathol. 2000 PMID: 10965989

Citations for Fluvastatin sodium (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Fluvastatin sodium include:

Park et al. (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 17:914
PMID: 27270401
Rojo-Arreola et al. (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One. 9:e87594
PMID: 24489942
Li and Fountain (2012) Fluvastatin suppresses native and recombinant human P2X4 receptor function. Purinergic Signal. 8:311
PMID: 22222818
Vainio et al. (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Am J Physiol Renal Physiol. 2:1176
PMID: 22202492
Bergman et al. (2011) Studies on the antibacterial effects of STAT--in vitro and in vivo. PLoS One. 6:e24394
PMID: 21912631

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