Flutamide
Tocris Bioscience, part of Bio-Techne | Catalog # 4094
Non-steroidal androgen receptor antagonist
Key Product Details
Description
Non-steroidal androgen receptor antagonist
Alternative Names
SCH 13521
Product Description
Flutamide is a non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone in vivo.Product Specifications
Molecular Weight
276.21
Formula
C11H11F3N2O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
CAS Number
13311-84-7
PubChem ID
3397
InChI Key
MKXKFYHWDHIYRV-UHFFFAOYSA-N
SMILES
CC(C)C(NC1=CC(C(F)(F)F)=C([N+]([O-])=O)C=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.62 | 100 | |
| Ethanol | 27.62 | 100 |
Preparing Stock Solutions
for Flutamide
The following data is based on the product molecular weight 276.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.10 mL | 36.20 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Butcher Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 2007 PMID: 17210686
- Foster Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate 2011 PMID: 20878947
- Sufrin and Coffey Flutamide. Mechanism of action of a new nonsteroidal antiandrogen. Invest.Urol. 1976 PMID: 1270239
Product Specific Notices for Flutamide
For research use only
⚠ WARNING: This product can expose you to chemicals including Flutamide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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